Barshop Institute Seminar of 29 August 12, 2012: "The role of mTOR signaling in Alzheimer;s disease: Therapeutic implications: Dr. Oddo's Research Interests: Overall, we use broad genetic approaches to modify the genome of animals with the goal of understanding the role of specific neuronal populations and for elucidating the molecular mechanisms underlying age-dependent neurodegenerative disorders, such as Alzheimer's disease and Frontotemporal dementia. These genetic approaches include direct manipulation of the mouse genome through the development of inducible transgenic mice and viral transduction mechanisms. Both of these approaches offer precise temporal control and regional specificity and can be superimposed with varying developmental stages of the CNS. The outcome of these studies will reveal critical molecular determinants underlying motor and cognitive dysfunction in the mammalian CNS.
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