Here we made two breakthroughs. One is the development of a very sensitive fluorescent probe that can detect neuronal activity. The other is the development of the genetic method to generate transgenic fish efficiently. Here we used transgenic zebrafish that express the calcium sensor GCaMP in the brain. A paramecium is swimming around the fish. When the eye recognizes the paramecium, the signals are transferred from eye to the brain and GCaMP shines in neurons that are activated. Commentary by Kawakami and Muto. This is a video abstract for Current Biology (www.cell.com
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